Erik Ullian, PhD

Professor in Residence
Ophthalmology
+1 415 476-1314
Publications: 

CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions.

bioRxiv : the preprint server for biology

Li E, Benitez C, Boggess SC, Koontz M, Rose IVL, Draeger N, Teter OM, Samelson AJ, Ullian EM, Kampmann M

Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies.

Science (New York, N.Y.)

Minhas PS, Jones JR, Latif-Hernandez A, Sugiura Y, Durairaj AS, Wang Q, Mhatre SD, Uenaka T, Crapser J, Conley T, Ennerfelt H, Jung YJ, Liu L, Prasad P, Jenkins BC, Ay YA, Matrongolo M, Goodman R, Newmeyer T, Heard K, Kang A, Wilson EN, Yang T, Ullian EM, Serrano GE, Beach TG, Wernig M, Rabinowitz JD, Suematsu M, Longo FM, McReynolds MR, Gage FH, Andreasson KI

Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies.

bioRxiv : the preprint server for biology

Minhas PS, Jones JR, Latif-Hernandez A, Sugiura Y, Durairaj AS, Uenaka T, Wang Q, Mhatre SD, Liu L, Conley T, Ennerfelt H, Jung YJ, Prasad P, Jenkins BC, Goodman R, Newmeyer T, Heard K, Kang A, Wilson EN, Ullian EM, Serrano GE, Beach TG, Rabinowitz JD, Wernig M, Suematsu M, Longo FM, McReynolds MR, Gage FH, Andreasson KI

Astroglial toxicity promotes synaptic degeneration in the thalamocortical circuit in frontotemporal dementia with GRN mutations.

The Journal of clinical investigation

Marsan E, Velmeshev D, Ramsey A, Patel RK, Zhang J, Koontz M, Andrews MG, de Majo M, Mora C, Blumenfeld J, Li AN, Spina S, Grinberg LT, Seeley W, Miller BL, Ullian EM, Krummel MF, Kriegstein A, Huang EJ

Granulin loss of function in human mature brain organoids implicates astrocytes in TDP-43 pathology.

Stem cell reports

de Majo M, Koontz M, Marsan E, Salinas N, Ramsey A, Kuo YM, Seo K, Li H, Dr?ger N, Leng K, Gonzales SL, Kurnellas M, Miyaoka Y, Klim JR, Kampmann M, Ward ME, Huang EJ, Ullian EM

Machine learning dissection of human accelerated regions in primate neurodevelopment.

Neuron

Whalen S, Inoue F, Ryu H, Fair T, Markenscoff-Papadimitriou E, Keough K, Kircher M, Martin B, Alvarado B, Elor O, Laboy Cintron D, Williams A, Hassan Samee MA, Thomas S, Krencik R, Ullian EM, Kriegstein A, Rubenstein JL, Shendure J, Pollen AA, Ahituv N, Pollard KS

TMIC-43. HEDGEHOG LIGANDS FROM GLIOBLASTOMA CELLS INDUCE ASTROCYTES INHIBITION OF CANCER STEM CELLS.

Neuro-Oncology

Kyounghee Seo, S John Liu, Vikas Daggubati, Joanna J Phillips, Jennifer Clarke, Michael Prados, Aparna Bhaduri, Daniel Lim, Erik Ullian, David Raleigh

CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states.

Nature neuroscience

Leng K, Rose IVL, Kim H, Xia W, Romero-Fernandez W, Rooney B, Koontz M, Li E, Ao Y, Wang S, Krawczyk M, Tcw J, Goate A, Zhang Y, Ullian EM, Sofroniew MV, Fancy SPJ, Schrag MS, Lippmann ES, Kampmann M

Tropism of SARS-CoV-2 for human cortical astrocytes.

Proceedings of the National Academy of Sciences of the United States of America

Andrews MG, Mukhtar T, Eze UC, Simoneau CR, Ross J, Parikshak N, Wang S, Zhou L, Koontz M, Velmeshev D, Siebert CV, Gemenes KM, Tabata T, Perez Y, Wang L, Mostajo-Radji MA, de Majo M, Donohue KC, Shin D, Salma J, Pollen AA, Nowakowski TJ, Ullian E, Kumar GR, Winkler EA, Crouch EE, Ott M, Kriegstein AR

Trans-Seq maps a selective mammalian retinotectal synapse instructed by Nephronectin.

Nature neuroscience

Tsai NY, Wang F, Toma K, Yin C, Takatoh J, Pai EL, Wu K, Matcham AC, Yin L, Dang EJ, Marciano DK, Rubenstein JL, Wang F, Ullian EM, Duan X

Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma.

Nature communications

Magill ST, Vasudevan HN, Seo K, Villanueva-Meyer JE, Choudhury A, John Liu S, Pekmezci M, Findakly S, Hilz S, Lastella S, Demaree B, Braunstein SE, Bush NAO, Aghi MK, Theodosopoulos PV, Sneed PK, Abate AR, Berger MS, McDermott MW, Lim DA, Ullian EM, Costello JF, Raleigh DR

Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency.

Nature

Zhang J, Velmeshev D, Hashimoto K, Huang YH, Hofmann JW, Shi X, Chen J, Leidal AM, Dishart JG, Cahill MK, Kelley KW, Liddelow SA, Seeley WW, Miller BL, Walther TC, Farese RV, Taylor JP, Ullian EM, Huang B, Debnath J, Wittmann T, Kriegstein AR, Huang EJ

CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma.

Genome biology

Liu SJ, Malatesta M, Lien BV, Saha P, Thombare SS, Hong SJ, Pedraza L, Koontz M, Seo K, Horlbeck MA, He D, Birk HS, Jain M, Olsen HE, Akeson M, Weissman JS, Monje M, Gupta N, Raleigh DR, Ullian EM, Lim DA

Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map.

Nature neuroscience

Bayraktar OA, Bartels T, Holmqvist S, Kleshchevnikov V, Martirosyan A, Polioudakis D, Ben Haim L, Young AMH, Batiuk MY, Prakash K, Brown A, Roberts K, Paredes MF, Kawaguchi R, Stockley JH, Sabeur K, Chang SM, Huang E, Hutchinson P, Ullian EM, Hemberg M, Coppola G, Holt MG, Geschwind DH, Rowitch DH

An update on human astrocytes and their role in development and disease.

Glia

de Majo M, Koontz M, Rowitch D, Ullian EM

GENE-39. CRISPRi-BASED RADIATION MODIFIER SCREEN IDENTIFIES LONG NON-CODING RNA THERAPEUTIC TARGETS IN GLIOMA.

Neuro-Oncology

S John Liu, Martina Malatesta, Kyounghee Seo, Brian Lien, Sung Hong, Mark Koontz, David Raleigh, Erik Ullian, Daniel Lim

TMOD-27. A NEURAL CREST CELL SUBPOPULATION UNDERLIES INTRATUMOR HETEROGENEITY IN MENINGIOMA.

Neuro-Oncology

Stephen Magill, Harish Vasudevan, Kyounghee Seo, S John Liu, Stephanie Hilz, Javier Villanueva-Meyer, Abrar Choudhury, Benjamin Demaree, Daniel Lim, Steve Braunstein, Nancy Ann Oberheim-Bush, Erik Ullian, Manish Aghi, Philip Theodosopoulos, Patricia Sneed, Adam Abate, Mitchel Berger, Mike McDermott, Joseph Costello, David Raleigh

COL4A1 Mutations Cause Neuromuscular Disease with Tissue-Specific Mechanistic Heterogeneity.

American journal of human genetics

Labelle-Dumais C, Schuitema V, Hayashi G, Hoff K, Gong W, Dao DQ, Ullian EM, Oishi P, Margeta M, Gould DB

TMOD-04. TARGETING A GLIOMA SPECIFIC lncRNA IN A HUMAN BRAIN ORGANOID TUMOR MODEL.

Neuro-Oncology

Martina Malatesta, John Liu, Leslie Pedraza, Kyounghee Seo, Elizabeth DiLullo, David Raleigh, Arnold Kriegstein, Erik Ullian, Daniel Lim

Proceedings of the fifth international RASopathies symposium: When development and cancer intersect.

American journal of medical genetics. Part A

Rauen KA, Schoyer L, Schill L, Stronach B, Albeck J, Andresen BS, Cavé H, Ellis M, Fruchtman SM, Gelb BD, Gibson CC, Gripp K, Hefner E, Huang WYC, Itkin M, Kerr B, Linardic CM, McMahon M, Oberlander B, Perlstein E, Ratner N, Rogers L, Schenck A, Shankar S, Shvartsman S, Stevenson DA, Stites EC, Stork PJS, Sun C, Therrien M, Ullian EM, Widemann BC, Yeh E, Zampino G, Zenker M, Timmer W, McCormick F

Kir4.1-Dependent Astrocyte-Fast Motor Neuron Interactions Are Required for Peak Strength.

Neuron

Kelley KW, Ben Haim L, Schirmer L, Tyzack GE, Tolman M, Miller JG, Tsai HH, Chang SM, Molofsky AV, Yang Y, Patani R, Lakatos A, Ullian EM, Rowitch DH

Clemastine rescues myelination defects and promotes functional recovery in hypoxic brain injury.

Brain : a journal of neurology

Cree BAC, Niu J, Hoi KK, Zhao C, Caganap SD, Henry RG, Dao DQ, Zollinger DR, Mei F, Shen YA, Franklin RJM, Ullian EM, Xiao L, Chan JR, Fancy SPJ

Cellular Phenotypes in Human iPSC-Derived Neurons from a Genetic Model of Autism Spectrum Disorder.

Cell reports

Deshpande A, Yadav S, Dao DQ, Wu ZY, Hokanson KC, Cahill MK, Wiita AP, Jan YN, Ullian EM, Weiss LA

Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes.

Stem cell reports

Krencik R, Seo K, van Asperen JV, Basu N, Cvetkovic C, Barlas S, Chen R, Ludwig C, Wang C, Ward ME, Gan L, Horner PJ, Rowitch DH, Ullian EM

Patient-derived iPSCs show premature neural differentiation and neuron type-specific phenotypes relevant to neurodevelopment.

Molecular psychiatry

Yeh E, Dao DQ, Wu ZY, Kandalam SM, Camacho FM, Tom C, Zhang W, Krencik R, Rauen KA, Ullian EM, Weiss LA

Human stem cell-derived astrocytes replicate human prions in a PRNP genotype-dependent manner.

The Journal of experimental medicine

Krejciova Z, Alibhai J, Zhao C, Krencik R, Rzechorzek NM, Ullian EM, Manson J, Ironside JW, Head MW, Chandran S

Zika virus cell tropism in the developing human brain and inhibition by azithromycin.

Proceedings of the National Academy of Sciences of the United States of America

Retallack H, Di Lullo E, Arias C, Knopp KA, Laurie MT, Sandoval-Espinosa C, Mancia Leon WR, Krencik R, Ullian EM, Spatazza J, Pollen AA, Mandel-Brehm C, Nowakowski TJ, Kriegstein AR, DeRisi JL

Selective Vulnerability of Specific Retinal Ganglion Cell Types and Synapses after Transient Ocular Hypertension.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Ou Y, Jo RE, Ullian EM, Wong RO, Della Santina L

Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes.

Stem cell reports

Josowitz R, Mulero-Navarro S, Rodriguez NA, Falce C, Cohen N, Ullian EM, Weiss LA, Rauen KA, Sobie EA, Gelb BD

Human astrocytes are distinct contributors to the complexity of synaptic function.

Brain research bulletin

Krencik R, van Asperen JV, Ullian EM

Dynamic Modulation of Myelination in Response to Visual Stimuli Alters Optic Nerve Conduction Velocity.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Etxeberria A, Hokanson KC, Dao DQ, Mayoral SR, Mei F, Redmond SA, Ullian EM, Chan JR

Human iPS Cell-Derived Neurons Uncover the Impact of Increased Ras Signaling in Costello Syndrome.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Rooney GE, Goodwin AF, Depeille P, Sharir A, Schofield CM, Yeh E, Roose JP, Klein OD, Rauen KA, Weiss LA, Ullian EM

Dysregulation of astrocyte extracellular signaling in Costello syndrome.

Science translational medicine

Krencik R, Hokanson KC, Narayan AR, Dvornik J, Rooney GE, Rauen KA, Weiss LA, Rowitch DH, Ullian EM

Abstract 19583: Autonomous and Non-Autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes.

Circulation

Rebecca Josowitz, Sonia Mulero-Navarro, Christine Falce, Ninette Cohen, Erik M Ullian, Lauren A Weiss, Katherine A Rauen, Eric A Sobie, Bruce D Gelb

Phosphorylation of LKB1/Par-4 establishes Schwann cell polarity to initiate and control myelin extent.

Nature communications

Shen YA, Chen Y, Dao DQ, Mayoral SR, Wu L, Meijer D, Ullian EM, Chan JR, Lu QR

Astrocyte-encoded positional cues maintain sensorimotor circuit integrity.

Nature

Molofsky AV, Kelley KW, Tsai HH, Redmond SA, Chang SM, Madireddy L, Chan JR, Baranzini SE, Ullian EM, Rowitch DH

Loss of microRNAs in pyramidal neurons leads to specific changes in inhibitory synaptic transmission in the prefrontal cortex.

Molecular and cellular neurosciences

Hsu R, Schofield CM, Dela Cruz CG, Jones-Davis DM, Blelloch R, Ullian EM

Astrocytes and disease: a neurodevelopmental perspective.

Genes & development

Molofsky AV, Krencik R, Krenick R, Ullian EM, Ullian E, Tsai HH, Deneen B, Richardson WD, Barres BA, Rowitch DH

Afadin, a Ras/Rap effector that controls cadherin function, promotes spine and excitatory synapse density in the hippocampus.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Beaudoin GM, Schofield CM, Nuwal T, Zang K, Ullian EM, Huang B, Reichardt LF

Chapter 39 Development of Retinogeniculate Projections.

Adler\u0027s Physiology of the Eye

S.M. Koch, E.M. Ullian

Neuronal pentraxins mediate silent synapse conversion in the developing visual system.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Koch SM, Ullian EM

Dact1 is a postsynaptic protein required for dendrite, spine, and excitatory synapse development in the mouse forebrain.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Okerlund ND, Kivimäe S, Tong CK, Peng IF, Ullian EM, Cheyette BN

Astrocytes and synaptic plasticity.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry

Barker AJ, Ullian EM

Delta-catenin regulates spine and synapse morphogenesis and function in hippocampal neurons during development.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Arikkath J, Peng IF, Ng YG, Israely I, Liu X, Ullian EM, Reichardt LF

Functional regulations of p120 catenin at presynaptic site in neuron cultures.

International Journal of Developmental Neuroscience

I. Feng. Peng, S-H. Lee, L. Reichardt, E. Ullian

Neuronal pentraxins mediate silent synapse conversion in the developing visual system.

International Journal of Developmental Neuroscience

E. Ullian

Synapses are regulated by the cytoplasmic tyrosine kinase Fer in a pathway mediated by p120catenin, Fer, SHP-2, and beta-catenin.

The Journal of cell biology

Lee SH, Peng IF, Ng YG, Yanagisawa M, Bamji SX, Elia LP, Balsamo J, Lilien J, Anastasiadis PZ, Ullian EM, Reichardt LF

Architecture and activity-mediated refinement of axonal projections from a mosaic of genetically identified retinal ganglion cells.

Neuron

Huberman AD, Manu M, Koch SM, Susman MW, Lutz AB, Ullian EM, Baccus SA, Barres BA

Developmental control of synaptic receptivity.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Barker AJ, Koch SM, Reed J, Barres BA, Ullian EM

Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Davis TH, Cuellar TL, Koch SM, Barker AJ, Harfe BD, McManus MT, Ullian EM

Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration.

Proceedings of the National Academy of Sciences of the United States of America

Cuellar TL, Davis TH, Nelson PT, Loeb GB, Harfe BD, Ullian E, McManus MT

New roles for astrocytes in developing synaptic circuits.

Communicative & integrative biology

Barker AJ, Ullian EM

Neuronal pentraxins mediate synaptic refinement in the developing visual system.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Bjartmar L, Huberman AD, Ullian EM, Rentería RC, Liu X, Xu W, Prezioso J, Susman MW, Stellwagen D, Stokes CC, Cho R, Worley P, Malenka RC, Ball S, Peachey NS, Copenhagen D, Chapman B, Nakamoto M, Barres BA, Perin MS

Extracellular Matrix Molecules and Formation of CNS Synapses.

Molecular Mechanisms of Synaptogenesis

Erik M. Ullian, Alexander Dityatev

Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis.

Cell

Christopherson KS, Ullian EM, Stokes CC, Mullowney CE, Hell JW, Agah A, Lawler J, Mosher DF, Bornstein P, Barres BA

Role for glia in synaptogenesis.

Glia

Ullian EM, Christopherson KS, Barres BA

Invulnerability of retinal ganglion cells to NMDA excitotoxicity.

Molecular and cellular neurosciences

Ullian EM, Barkis WB, Chen S, Diamond JS, Barres BA

Schwann cells and astrocytes induce synapse formation by spinal motor neurons in culture.

Molecular and cellular neurosciences

Ullian EM, Harris BT, Wu A, Chan JR, Barres BA

Control of synapse number by glia.

Science (New York, N.Y.)

Ullian EM, Sapperstein SK, Christopherson KS, Barres BA

The Schwann song of the glia-less synapse.

Neuron

Ullian EM, Barres BA

Rapid synaptic transmission in the avian ciliary ganglion is mediated by two distinct classes of nicotinic receptors.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Ullian EM, McIntosh JM, Sargent PB

Pronounced cellular diversity and extrasynaptic location of nicotinic acetylcholine receptor subunit immunoreactivities in the chicken pretectum.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Ullian EM, Sargent PB

Receptor localization.

International Symposium on Nicotine: The Effects of Nicotine on Biological Systems II

P. B. Sargent, H. L. Wilson, E. M. Ullian, Reinhard Marks, John Lindstrom, Hannsjórg Schröder, M. Piattoni-Kaplan, D. Donnelly-Roberts, J. Pauly, D. Hill, J. B. Pan, S. P. Arneric, J. P. Sullivan, I. Aubert, D. Cécyre, S. Gauthier, R. Ouirion